| 24.10.2021 | Score |
|---|
| 21:30 |  Portimonense - GD Estoril Praia | |
| 21:00 | Atletico Madrid - Real Sociedad | |
| 21:00 | Leuven - Sint-Truidense | |
| 20:45 | Inter Milan - Juventus Turin | |
| 20:45 | Olympique de Marseille - Paris Saint German | |
| 20:00 | GKS Piast Gliwice - Legia Warszawa | |
| 19:30 | VFL Bochum - Eintracht Frankfurt | |
| 19:00 | Vizela - Benfica Lisbon | |
| 18:30 | Betis Sevilla - Real Valladolid | |
| 18:30 | KRC Genk - KAA Gent | |
| 18:00 | AS Roma - SSC Napoli | |
| 18:00 | Widzew Lodz - LKS Lodz | |
| 17:30 | KS Warta Poznan - Stal Mielec | |
| 17:30 | Manchester United FC - Liverpool FC | |
| 17:30 | VFB Stuttgart - FC Union Berlin | |
| 17:00 | AS Monaco FC - Montpellier | |
| 17:00 | RB Salzburg - SK Sturm Graz | |
| 16:30 | FC Basel - FC Lugano | |
| 16:30 | Pacos Ferreira - FC Arouca | |
| 16:30 | Servette - FC Sion | |
| 16:15 | FC Barcelona - Real Madrid | |
| 16:00 | Anderlecht - K Beerschot VA | |
| 16:00 | Flensburg Handewitt - Bittenfeld | |
| 16:00 | Fuchse Berlin - TUS N Lubbecke | |
| 16:00 | HSG Wetzlar - Rhein Neckar Lowen | |
| 16:00 | Minden Hannover - Tbv Lemgo Lippe | |
| 16:00 | Nottingham Forest - Fulham FC | |
| 16:00 | Queens Park FC - Alloa Athl. | |
| 15:30 | FC Koln - Bayer Leverkusen | |
| 15:00 | Brentford - Leicester City | |
| 15:00 | FC Lorient - Bordeaux | |
| 15:00 | Fiorentina - Cagliari | |
| 15:00 | Odra Opole - GKS Jastrzebie | |
| 15:00 | RC Lens - FC Metz | |
| 15:00 | Stade Reims - ES Troyes AC | |
| 15:00 | Stade Rennais FC - Strasbourg | |
| 15:00 | Verona - Lazio Roma | |
| 15:00 | West Ham United - Tottenham Hotspur | |
| 15:00 | Zaglebie Lubin - Cracovia Krakow | |
| 14:30 | LASK Linz - Rheindorf Altach | |
| 14:30 | TSV Hartberg - SK Rapid Vienna | |
| 14:15 | FC Luzern - FC ST Gallen 1879 | |
| 14:00 | FC Sevilla - FC Levante | |
| 14:00 | THW Kiel - SC Magdeburg | |
| 14:00 | Vendsyssel FF - FC Helsingor | |
| 13:30 | Barnsley FC - Sheffield United FC | |
| 13:30 | FC Antwerp - Club Brugge | |
| 13:00 | FC St Mirren - Rangers FC | |
| 13:00 | OGC Nice - Olympique Lyon | |
| 12:40 | Zaglebie Sosnowiec - Podbeskidzie Bielsko-Biala | |
| 12:30 | Atalanta BC - Udinese Calcio | |
| 04:00 | Jamel Herring - Shakur Stevenson | |
| 23.10.2021 | Score |
|---|
| 21:30 | Sporting Lisbon - Moreirense FC | |
| 21:00 | Athletic Club Bilbao - Villarreal CF | |
| 21:00 | FC Lille Sud - Dinamo Brest | |
| 20:45 | FC Bologna - AC Milan | |
| 20:45 | KAS Eupen - Union Saint-Gilloise | |
| 20:30 | GKS Tychy 71 - Skra Czestochowa | |
| 20:30 | Grasshopperss - FC Zurich | |
| 20:00 | Wisla Krakow SA - WKS Slask Wroclaw | |
| 19:00 | AC Ajaccio - AS Nancy-Lorraine | |
| 19:00 | AC Le Havre - Pau | |
| 19:00 | CD Tondela - FC Porto | |
| 19:00 | Chamois Niort FC - Rodez Aveyron | |
| 19:00 | FC Sochaux - US Quevilly Rouen Metropole | |
| 19:00 | Grenoble Foot - Dijon FCO | |
| 19:00 | Guingamp - Olympique Nimes | |
| 19:00 | SC Amiens - Valenciennes FC | |
| 19:00 | USL Dunkerque - SM Caen | |
| 18:30 | Brighton Hove Albion - Manchester City | |
| 18:30 | Elche - RCD Espanyol | |
| 18:30 | Hertha Berlin - Borussia M'gladbach | |
| 18:30 | KV Kortrijk - KV Oostende | |
| 18:30 | Mechelen - Zulte-Waregem | |
| 18:00 | GKS Dospel Katowice - MKS Puszcza Niepolomice | |
| 18:00 | US Sassuolo - Venezia FC | |
| 18:00 | Young Boys - FC Lausanne-Sports | |
| 17:30 | MKS Pogon Stettin - Jagiellonia | |
| 17:00 | Admira - WSG Tirol | |
| 17:00 | Asco Atsv Wolfsberg - Austria Klagenfurt | |
| 17:00 | Austria Wien - SV Josko Fenster Ried | |
| 17:00 | FC Nantes - Clermont Foot | |
| 16:30 | CD Santa Clara - FC Famalicao | |
| 16:30 | Roda JC Kirchrath - FC Emmen | |
| 16:15 | Cadiz - Deportivo Alaves | |
| 16:15 | Cercle Bruges - Standard Liege | |
| 16:00 | Aberdeen FC - Hibernian Lfc | |
| 16:00 | Bolton Wanderers - FC Gillingham | |
| 16:00 | Bournemouth AFC - Huddersfield Town FC | |
| 16:00 | Burton - Oxford | |
| 16:00 | Cove Rangers FC - Clyde | |
| 16:00 | Crystal Palace - Newcastle United | |
| 16:00 | Everton - Watford | |
| 16:00 | FC Rochdale - Sutton United FC | |
| 16:00 | Forest Green Rovers - Salford City FC | |
| 16:00 | Hartlepool United Fc - Harrogate Town | |
| 16:00 | Ipswich Town - Fleetwood Town XI | |
| 16:00 | Leeds United AFC - Wolverhampton | |
| 16:00 | Peterhead FC - Falkirk | |
| 16:00 | Port Vale FC - Colchester United | |